Publications

Publications

 

Complete list of publications >>

 

Selected publications:

“Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity”
Gersch M, Wagstaff JL, Toms AV, Graves B, Freund SMV, Komander D,
Mol Cell, 2019, 74, 436–451.


 “Mechanism and regulation of the Lys6-selective deubiquitinase USP30”
Gersch M, Gladkova C, Schubert A, Michel M, Maslen S, Komander D,
Nat Struct Mol Biol, 2017, 24(11), 920–930. (Also highlighted in Nat Chem Biol).

“Barrel-shaped ClpP proteases display attenuated cleavage specificities”
Gersch M, Stahl M, Poreba M, Dahmen M, Dziedzic A, Drag M, Sieber SA
ACS Chem Biol, 2016, 19(11), 389–399.


“AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control”
Gersch M, Famulla K, Dahmen M, Goebl C, Malik I, Richter K, Korotkov VS, Sass P, Ruebsamen-Schaeff H, Madl T, Broetz-Oesterhelt H, Sieber SA,
Nat Commun, 2015, 19(6), 6320.


“Intact protein mass spectrometry of 20S proteasomes reveals complex integrity, phosphorylation stoichiometry and inhibitor specificity”
Gersch M, Hackl M, Dubiella C, Dobrinevski A, Groll M, Sieber SA,
Chem Biol, 2015, 22(3), 404–411.


"Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition"
Gersch M, Kolb R, Alte F, Groll M, Sieber SA,
J Am Chem Soc, 2014, 136(4),1360–1366.


"The Mechanism of ClpP Inhibition",
Gersch M, Gut F, Korotkov V, Lehmann J, Böttcher T, Rusch M, Hedberg C, Waldmann H, Klebe G, Sieber SA,
Angew Chem Int Ed, 2013, 52(10), 3009–3014.


"Electrophilic natural products and their biological targets",
Gersch M, Kreuzer J, Sieber SA,
Nat Prod Rep, 2012, 29, 659–682. (Review)


"Insights into the structural network responsible for oligomerization and activity of the bacterial virulence regulator caseinolytic protease P (ClpP)"
Gersch M, List A, Groll M, Sieber SA,
J Biol Chem, 2012, 287(12), 9484–9494.

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