The Peng Wu Group is interested in the development of novel small molecule-based chemical modulators to manipulate the pervasive protein-RNA interactions, which impact almost all cellular events. Deregulations of the complex protein-RNA network are associated with various human diseases, while very limited modulation approaches are available. We aim to develop a platform strategy to tackle the challenging protein-RNA interactions. The first approach of our research is to use charged molecular machineries to disrupt the potent interactions between RNAs and RNA-binding proteins.
The second one is to apply a molecular recruiter to achieve targeted degradation of RNAs. Another approach is to assemble a covalently-modified dual function molecule to target RNA-binding proteins for induced activation or deactivation. We investigate these approaches to discover chemical probes that unfold the biological mechanisms of protein-RNA regulatory networks and provide drug leads for small molecule-based therapeutics with new mechanisms of action.