News

NEW PUBLICATIONS

A translational repression reporter assay for the analysis of RNA-binding protein consensus sites.

Nowacki J., Malenica M., Schmeing S., Schiller D., Buchmuller B., ‘t Hart P.
_{bioRxiv, DOI: 10.1101/2022.09.05.506580}

Development of Macrocyclic PRMT5 Adaptor Protein Interaction Inhibitors.

Krzyzanowski A., Esser L.M., Willaume A., Prudent R., Peter C., ‘t Hart P., Waldmann H.
_{J. Med. Chem., 2022, DOI: https://doi.org/10.1021/acs.jmedchem.2c01273} more

Solid‐phase peptide modification via deaminative photochemical Csp3‐Csp3 bond formation using Katritzky salts.

Openy J., Amrahova G., Chang J., Noisier A., ‘t Hart P.
_{Chem. Eur. J. 28:e202201121, (2022)}

RNA-Binding Macrocyclic Peptides Front.

Sunit P., 't Hart P.
_{Mol. Biosci. 2022; 9: 883060.}

Structural basis for specific inhibition of the deubiquitinase UCHL1

Grethe C, Schmidt M, Kipka GM, O'Dea R, Gallant K, Janning P, Gersch M,
_{Nat Commun. 2022, 13(1), 5950. doi} more

Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents.

J. Hwang, X. Qiu, L. Borgelt, N. Haacke, L. Kanis S. Petroulia, R. Gasper, D. Schiller, P. Lampe, S. Sievers, J. Imig , P. Wu.
_{Bioorg. Med. Chem. 58 (2022) 116653} more

Small molecules with tetrahydroquinoline-containing Povarov scaffolds as inhibitors disrupting the ProteineRNA interaction of LIN28-let-7.

Georg L. Goebel, Lisa Hohnen, Lydia Borgelt, Pascal Hommen, Xiaqiu Qiu, Helen Lightfoot , Peng Wu
_{European Journal of Medicinal Chemistry 228, 114014, S. 1 - 14, January, 2022} more

ERC Sarting Grant for Peter ‘t Hart

Peng Wu received the ICBS award

Boehringer Ingelheim Foundation supports research of Dr. Peter ‘t Hart

Sunit Pal receives highly-coveted Marie Sklodowska-Curie Postdoctoral Fellowship

Max Planck Institute of Molecular Physiology has been awarded a grant rom the Bundesministeriums für Bildung und Forschung (BMBF)

Dr. Peng Wu will receive research funding from the Exploration Grants programme

Peng Wu received the 2020SCT Award for Young Investigator in Medicinal Chemistry

VolkswagenStiftung supports corona research in Dortmund

Malte Gersch accepted to the Young College of the NRW Academy of Sciences, Humanities and the Art

Malte Gersch's team is looking for new ways to develop innovative therapeutic approaches.

CGC Symposium 2019 and Arrival of the 4. Group leader Dr. Jochen Imig at the CGC

Systems Biology of LncRNA and MiRNA Networks in Cancer

Malte Gersch, Group Leader at Chemical Genomics Centre

Dr. Malte Gersch

Peter 't Hart, Group Leader at Chemical Genomics Centre

Dr. Peter ‘t Hart received his bachelor degree in Chemistry from the Rotterdam University of Applied Sciences and went on to obtain his MSc degree from Utrecht University in Pharmacy.

Peng Wu, Group Leader at Chemical Genomics Centre

Dr. Peng Wu received his Doctoral Degree in Medicinal Chemistry from Zhejiang University in 2012. H