News

NEW PUBLICATIONS

Petasis sequence reactions for the scaffold-diverse synthesis of bioactive polycyclic small molecules.

A. Avathan Veettil, J. Kirchhoff, L. Brieger, C. Strohmann, P. Wu.
_{ACS Omega. 2022, http://doi.org/10.1021/acsomega.2c06585} more

Small molecule screening of ribonuclease L binders for RNA degradation.

L. Borgelt, N. Haacke, P. Lampe, X. Qiu, R. Gasper, D. Schiller, D. Summerer, S. Sievers, P. Wu.
_{Biomed. Pharmacother.}_{2022, 154, 113589. DOI: 10.1016/j.biopha.2022.113589.} more

Kinase-targeting small-molecule inhibitors and emerging bifunctional molecules.

G. Goebel, X, Qiu, P. Wu.
_{Trends Pharmacol. Sci.}_{2022, 43 (10), 866–881. DOI: >10.1016/j.tips.2022.04.006.} more

Cyclobutane-containing scaffolds in bioactive small molecules.

C. Hui, Y. Liu, M. Jiang, P. Wu.
_{Trends Chem. 2022, 4 (8), 677–681. DOI: 10.1016/j.trechm.2022.04.006.} more

A translational repression reporter assay for the analysis of RNA-binding protein consensus sites.

Nowacki J., Malenica M., Schmeing S., Schiller D., Buchmuller B., ‘t Hart P.
_{bioRxiv, DOI: 10.1101/2022.09.05.506580}

Development of Macrocyclic PRMT5 Adaptor Protein Interaction Inhibitors.

Krzyzanowski A., Esser L.M., Willaume A., Prudent R., Peter C., ‘t Hart P., Waldmann H.
_{J. Med. Chem., 2022, DOI: https://doi.org/10.1021/acs.jmedchem.2c01273} more

Solid‐phase peptide modification via deaminative photochemical Csp3‐Csp3 bond formation using Katritzky salts.

Openy J., Amrahova G., Chang J., Noisier A., ‘t Hart P.
_{Chem. Eur. J. 28:e202201121, (2022)}

RNA-Binding Macrocyclic Peptides Front.

Sunit P., 't Hart P.
_{Mol. Biosci. 2022; 9: 883060.}

Structural basis for specific inhibition of the deubiquitinase UCHL1

Grethe C, Schmidt M, Kipka GM, O'Dea R, Gallant K, Janning P, Gersch M,
_{Nat Commun. 2022, 13(1), 5950. doi} more

Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents.

J. Hwang, X. Qiu, L. Borgelt, N. Haacke, L. Kanis S. Petroulia, R. Gasper, D. Schiller, P. Lampe, S. Sievers, J. Imig , P. Wu.
_{Bioorg. Med. Chem. 58 (2022) 116653} more

Small molecules with tetrahydroquinoline-containing Povarov scaffolds as inhibitors disrupting the ProteineRNA interaction of LIN28-let-7.

Georg L. Goebel, Lisa Hohnen, Lydia Borgelt, Pascal Hommen, Xiaqiu Qiu, Helen Lightfoot , Peng Wu
_{European Journal of Medicinal Chemistry 228, 114014, S. 1 - 14, January, 2022} more

NEW PUBLICATIONS

Petasis sequence reactions for the scaffold-diverse synthesis of bioactive polycyclic small molecules.

Small molecule screening of ribonuclease L binders for RNA degradation.

Kinase-targeting small-molecule inhibitors and emerging bifunctional molecules.

Cyclobutane-containing scaffolds in bioactive small molecules.

A translational repression reporter assay for the analysis of RNA-binding protein consensus sites.

Development of Macrocyclic PRMT5 Adaptor Protein Interaction Inhibitors.

Solid‐phase peptide modification via deaminative photochemical Csp3‐Csp3 bond formation using Katritzky salts.

RNA-Binding Macrocyclic Peptides Front.

Structural basis for specific inhibition of the deubiquitinase UCHL1

Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents.

Small molecules with tetrahydroquinoline-containing Povarov scaffolds as inhibitors disrupting the ProteineRNA interaction of LIN28-let-7.

Trisubstituted Pyrrolinones as Small-Molecule Inhibitors Disrupting the Protein–RNA Interaction of LIN28 and Let-7

Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5-MEP50 Complex

Multicomponent Petasis Reaction for the Synthesis of Functionalized 2-Aminothiophenes and Thienodiazepines

Optochemical Control of Protein Degradation

Inhibition of RNA-binding proteins with small molecules

ERC Sarting Grant for Peter ‘t Hart

Peng Wu received the ICBS award

Boehringer Ingelheim Foundation supports research of Dr. Peter ‘t Hart

Sunit Pal receives highly-coveted Marie Sklodowska-Curie Postdoctoral Fellowship

Max Planck Institute of Molecular Physiology has been awarded a grant from the Bundesministeriums für Bildung und Forschung (BMBF)

Dr. Peng Wu will receive research funding from the Exploration Grants programme

Peng Wu received the 2020SCT Award for Young Investigator in Medicinal Chemistry

VolkswagenStiftung supports corona research in Dortmund

Malte Gersch accepted to the Young College of the NRW Academy of Sciences, Humanities and the Art

CGC Symposium 2019 and Arrival of the 4. Group leader
Dr. Jochen Imig at the CGC

Malte Gersch, Group Leader at Chemical Genomics Centre

Peter 't Hart, Group Leader at Chemical Genomics Centre

Peng Wu, Group Leader at Chemical Genomics Centre

Chemical Genomics Centre begins new funding period

NEW PUBLICATIONS

A translational repression reporter assay for the analysis of RNA-binding protein consensus sites.

Solid‐phase peptide modification via deaminative photochemical Csp3‐Csp3 bond formation using Katritzky salts.

RNA-Binding Macrocyclic Peptides Front.

NEWS

ERC Sarting Grant for Peter ‘t Hart

Peng Wu received the ICBS award

Boehringer Ingelheim Foundation supports research of Dr. Peter ‘t Hart

Sunit Pal receives highly-coveted Marie Sklodowska-Curie Postdoctoral Fellowship

Max Planck Institute of Molecular Physiology has been awarded a grant from the Bundesministeriums für Bildung und Forschung (BMBF)

Dr. Peng Wu will receive research funding from the Exploration Grants programme

Peng Wu received the 2020SCT Award for Young Investigator in Medicinal Chemistry

VolkswagenStiftung supports corona research in Dortmund

Malte Gersch accepted to the Young College of the NRW Academy of Sciences, Humanities and the Art

CGC Symposium 2019 and Arrival of the 4. Group leaderDr. Jochen Imig at the CGC

Malte Gersch, Group Leader at Chemical Genomics Centre

Peter 't Hart, Group Leader at Chemical Genomics Centre

Peng Wu, Group Leader at Chemical Genomics Centre

Chemical Genomics Centre begins new funding period

CGC Symposium 2019 and Arrival of the 4. Group leader
Dr. Jochen Imig at the CGC