't Hart Lab

't Hart Lab


List of Publications (link to PubMed) >>>



Jen-Yao Chang,a Cora Neugebauer,a Stefan Schmeing,a Gulshan Amrahovaa  and  Peter ‘t Hart*a
Macrocyclic peptides as inhibitors of WDR5–lncRNA interactions
Chem. Commun., 2023, Advance Article, https://pubs.rsc.org/en/content/articlelanding/2023/CC/D3CC03221C

Schmeing S., Amrahova G., Bigler K., Chang J.-Y., Joseph Openy J., Pal S.,  Posada L., Gasper R. and 't Hart P. 
Rationally designed stapled peptides allosterically inhibit PTBP1 RNA-binding”
Chem. Sci., 2023,14, 8269-8278 , https://pubs.rsc.org/en/content/articlelanding/2023/sc/d3sc00985h

Pal S., Openy J., Krzyzanowski A., Noisier A., 't Hart P., 2023
"On-resin Photochemical Decarboxylative Arylation of Peptides."
chemRxiv, https://doi.org/10.26434/chemrxiv-2023-9kk2v

Nowacki J., Malenica M., Schmeing S., Schiller D., Buchmuller B., Amrahova, G., ‘t Hart P. 2023
“A translational repression reporter assay for the analysis of RNA-binding protein consensus sites.”
RNA Biology, 20(1); 85-94


Nowacki J., Malenica M., Schmeing S., Schiller D., Buchmuller B., ‘t Hart P. 2022
“A translational repression reporter assay for the analysis of RNA-binding protein consensus sites.”
bioRxiv DOI: 10.1101/2022.09.05.506580

Krzyzanowski A., Esser L.M., Willaume A., Prudent R., Peter C., ‘t Hart P., Waldmann H. 2022.
“Development of Macrocyclic PRMT5 Adaptor Protein Interaction Inhibitors.”
J. Med. Chem. DOI: https://doi.org/10.1021/acs.jmedchem.2c01273

Openy J., Amrahova G., Chang J., Noisier A., ‘t Hart P. 2022.
“Solid‐phase peptide modification via deaminative photochemical Csp3‐Csp3 bond formation using Katritzky salts.”
Chem. Eur. J. 28:e202201121

Sunit P., 't Hart P.
“RNA-Binding Macrocyclic Peptides Front.”
Mol. Biosci. 2022; 9: 883060.


Krzyzanowski, A., Gasper, R., Adihou, H., ’t Hart, P., Waldmann, H., 2021.
“Biochemical Investigation of the Interaction of PICln, RioK1 and COPR5 with the PRMT5–MEP50 Complex.”
ChemBioChem 22(11):1908–14

‘t Hart, P., Hommen, P., Noisier, A., Krzyzanowski, A., Schüler, D., Porfetye, A.T, Akbarzadeh, M., Vetter, I.R., Adihou, H., Waldmann, H., 2021.
“Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48.”
Angewandte Chemie International Edition 60(4):1813–20


‘t Hart, P., Openy, J., Krzyzanowski, A., Adihou, H., Waldmann, H., 2019.
“Hot-Spot Guided Design of Macrocyclic Inhibitors of the LSD1-CoREST1 Interaction.”
Tetrahedron 75(48).


le Paige, U. B., Smits, B., t Hart, P., Lefeber, F., Martin, N.I., van Ingen, H., 2017.
“Weak Coupling between Magnetically Inequivalent Spins: The Deceptively Simple, Complicated Spectrum of a13C-Labeled Trimethylated Amine.”
Journal of Magnetic Resonance 278:96-103

’t Hart, P., Wood, T.M., Tehrani, K.H.M.E., van Harten, R.M., Śleszyńska, M., Rentero Rebollo, I., Hendrickx, A.P.A., Willems, R.J.L., Breukink, E., Martin, N.I., 2017.
“De Novo Identification of Lipid II Binding Lipopeptides with Antibacterial Activity against Vancomycin-Resistant Bacteria.”
Chemical Science 8(12):7991–97


Kleijn, L. H. J., Oppedijk, S. F., ‘t Hart, P., van Harten, R.M., Martin-Visscher, L.A., Kemmink, J., Breukink, E., Martin, N.I., 2016.
“Total Synthesis of Laspartomycin C and Characterization of Its Antibacterial Mechanism of Action.”
Journal of Medicinal Chemistry 59(7):3569–74

’t Hart, P., Oppedijk, S.F., Breukink, E., Martin, N.I., 2016.
“New Insights into Nisin’s Antibacterial Mechanism Revealed by Binding Studies with Synthetic Lipid II Analogues.”
Biochemistry 55(1):232–37


Koopmans, T., Wood, T.M., ’t Hart, P., Kleijn, L.H.J., Hendrickx, A.P.A., Willems, R.J.L., Breukink, E., Martin, N.I., 2015.
“Semisynthetic Lipopeptides Derived from Nisin Display Antibacterial Activity and Lipid II Binding on Par with That of the Parent Compound.”
Journal of the American Chemical Society 137(29):9382–89


Mooney, C.A., Johnson, S.A., ’t Hart, P., Quarles van Ufford, L., de Haan, C.A.M., Moret, E.E., Martin. N.I., 2014.
“Oseltamivir Analogues Bearing N-Substituted Guanidines as Potent Neuraminidase Inhibitors.”
Journal of Medicinal Chemistry 57(7):3154–60

‘t Hart, P., Kleijn, L.H.J., de Bruin, G., Oppedijk, S.F., Kemmink, J., Martin, N.I., 2014.
“A Combined Solid- and Solution-Phase Approach Provides Convenient Access to Analogues of the Calcium-Dependent Lipopeptide Antibiotics.”
Organic & Biomolecular Chemistry 12(6):913–18


‘t Hart, P.*, Thomas, D.*, Van Ommeren, R., Lakowski, T.M., Frankel, A., Martin, N.I., 2012.
“Analogues of the HIV-Tat Peptide Containing Nη-Modified Arginines as Potent Inhibitors of Protein Arginine N-Methyltransferases.”
MedChemComm 3(10)


’t Hart, P.*, Lakowski, T.M.*, Thomas, D., Frankel, A., Martin, N.I., 2011.
“Peptidic Partial Bisubstrates as Inhibitors of the Protein Arginine N-Methyltransferases.”
ChemBioChem 12(9):1427–32


Lakowski, T. M.*, ‘t Hart, P.*, Ahern, C.A., Martin, N.I., Frankel, A. 2010.
“Nη-Substituted Arginyl Peptide Inhibitors of Protein Arginine N-Methyltransferases.”
ACS Chemical Biology 5(11):1053–63.
*equal contribution

Go to Editor View