't Hart Lab
PUBLICATIONS
List of Publications (link to PubMed) >>>
2024
Pal, S., ‘t Hart, P., 2024.
“Imbuing peptide libraries with drug-likeness.”
Nat. Chem. Biol. 20, 140–141. https://www.nature.com/articles/s41589-023-01524-x
Chang, J.Y., Neugebauer, C., Mues genannt Koers, A., ‘t Hart, P., 2024.
“Small molecule WDR5 inhibitors down-regulate lncRNA expression.”
RSC Med. Chem. 15, 636–640. https://pubs.rsc.org/en/content/articlelanding/2024/md/d3md00605k
2023
Chang, J.Y., Neugebauer, C., Schmeing, S., Amrahovaa, G., ‘t Hart, P., 2023.
“Macrocyclic peptides as inhibitors of WDR5–lncRNA interactions.”
Chem. Commun. 59, 10656–10659. https://pubs.rsc.org/en/content/articlelanding/2023/CC/D3CC03221C
Schmeing, S., Amrahova, G., Bigler, K., Chang, J.Y., Openy, J., Pal, S., Posada, L., Gasper, R. and 't Hart P., 2023.
“Rationally designed stapled peptides allosterically inhibit PTBP1 RNA-binding.”
Chem. Sci. 14, 8269–8278 , https://pubs.rsc.org/en/content/articlelanding/2023/sc/d3sc00985h
Pal, S., Openy, J., Krzyzanowski, A., Noisier, A., 't Hart, P., 2023.
"On-resin Photochemical Decarboxylative Arylation of Peptides."
Org. Lett. https://doi.org/10.1021/acs.orglett.3c03070
Nowacki, J., Malenica, M., Schmeing, S., Schiller, D., Buchmuller, B., Amrahova, G., ‘t Hart P., 2023.
“A translational repression reporter assay for the analysis of RNA-binding protein consensus sites.”
RNA Biology, 20(1); 85–94 https://pubmed.ncbi.nlm.nih.gov/36946649
2022
Nowacki, J., Malenica, M., Schmeing, S., Schiller, D., Buchmuller, B., ‘t Hart P., 2022.
“A translational repression reporter assay for the analysis of RNA-binding protein consensus sites.”
bioRxiv. https://www.biorxiv.org/content/10.1101/2022.09.05.506580v1
Krzyzanowski, A., Esser, L.M., Willaume, A., Prudent, R., Peter, C., ‘t Hart. P., Waldmann, H., 2022.
“Development of Macrocyclic PRMT5 Adaptor Protein Interaction Inhibitors.”
J. Med. Chem. https://doi.org/10.1021/acs.jmedchem.2c01273
Openy, J., Amrahova, G., Chang, J., Noisier, A., ‘t Hart, P., 2022.
“Solid‐phase peptide modification via deaminative photochemical Csp3‐Csp3 bond formation using Katritzky salts.”
Chem. Eur. J. 28:e202201121. https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202201121
Pal, S., 't Hart, P., 2022.
“RNA-Binding Macrocyclic Peptides.” Front Mol. Biosci. 9: 883060. https://www.frontiersin.org/articles/10.3389/fmolb.2022.883060/full
2021
Krzyzanowski, A., Gasper, R., Adihou, H., ’t Hart, P., Waldmann, H., 2021.
“Biochemical Investigation of the Interaction of PICln, RioK1 and COPR5 with the PRMT5–MEP50 Complex.”
ChemBioChem 22(11):1908–14. https://pubmed.ncbi.nlm.nih.gov/33624332/
‘t Hart, P., Hommen, P., Noisier, A., Krzyzanowski, A., Schüler, D., Porfetye, A.T., Akbarzadeh, M., Vetter, I.R., Adihou, H., Waldmann, H., 2021.
“Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48.”
Angewandte Chemie International Edition. 60(4):1813–20. https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202009749
2019
‘t Hart, P., Openy, J., Krzyzanowski, A., Adihou, H., Waldmann, H., 2019.
“Hot-Spot Guided Design of Macrocyclic Inhibitors of the LSD1-CoREST1 Interaction.”
Tetrahedron. 75(48). https://www.sciencedirect.com/science/article/abs/pii/S0040402019310609
2017
le Paige, U.B., Smits, B., ‘t Hart, P., Lefeber, F., Martin, N.I., van Ingen, H., 2017.
“Weak Coupling between Magnetically Inequivalent Spins: The Deceptively Simple, Complicated Spectrum of a13C-Labeled Trimethylated Amine.”
Journal of Magnetic Resonance. 278:96–103. https://pubmed.ncbi.nlm.nih.gov/28391179/
’t Hart, P., Wood, T.M., Tehrani, K.H.M.E., van Harten, R.M., Śleszyńska, M., Rentero Rebollo, I., Hendrickx, A.P.A., Willems, R.J.L., Breukink, E., Martin, N.I., 2017.
“De Novo Identification of Lipid II Binding Lipopeptides with Antibacterial Activity against Vancomycin-Resistant Bacteria.”
Chemical Science. 8(12):7991–97. https://pubs.rsc.org/en/content/articlelanding/2017/sc/c7sc03413j
2016
Kleijn, L.H.J., Oppedijk, S.F., ‘t Hart, P., van Harten, R.M., Martin-Visscher, L.A., Kemmink, J., Breukink, E., Martin, N.I., 2016.
“Total Synthesis of Laspartomycin C and Characterization of Its Antibacterial Mechanism of Action.”
Journal of Medicinal Chemistry. 59(7):3569–74. https://pubs.acs.org/doi/10.1021/acs.jmedchem.6b00219
’t Hart, P., Oppedijk, S.F., Breukink, E., Martin, N.I., 2016.
“New Insights into Nisin’s Antibacterial Mechanism Revealed by Binding Studies with Synthetic Lipid II Analogues.”
Biochemistry. 55(1):232–37. https://pubs.acs.org/doi/10.1021/acs.biochem.5b01173
2015
Koopmans, T., Wood, T.M., ’t Hart, P., Kleijn, L.H.J., Hendrickx, A.P.A., Willems, R.J.L., Breukink, E., Martin, N.I., 2015.
“Semisynthetic Lipopeptides Derived from Nisin Display Antibacterial Activity and Lipid II Binding on Par with That of the Parent Compound.”
Journal of the American Chemical Society. 137(29):9382–89. https://pubs.acs.org/doi/10.1021/jacs.5b04501
2014
Mooney, C.A., Johnson, S.A., ’t Hart, P., Quarles van Ufford, L., de Haan, C.A.M., Moret, E.E., Martin. N.I., 2014.
“Oseltamivir Analogues Bearing N-Substituted Guanidines as Potent Neuraminidase Inhibitors.”
Journal of Medicinal Chemistry. 57(7):3154–60. https://pubs.acs.org/doi/10.1021/jm401977j
‘t Hart, P., Kleijn, L.H.J., de Bruin, G., Oppedijk, S.F., Kemmink, J., Martin, N.I., 2014.
“A Combined Solid- and Solution-Phase Approach Provides Convenient Access to Analogues of the Calcium-Dependent Lipopeptide Antibiotics.”
Organic & Biomolecular Chemistry. 12(6):913–18. https://pubs.rsc.org/en/content/articlehtml/2014/ob/c3ob42238k
2012
‘t Hart, P.*, Thomas, D.*, Van Ommeren, R., Lakowski, T.M., Frankel, A., Martin, N.I., 2012.
“Analogues of the HIV-Tat Peptide Containing Nη-Modified Arginines as Potent Inhibitors of Protein Arginine N-Methyltransferases.”
MedChemComm. 3(10). https://pubs.rsc.org/en/content/articlelanding/2012/md/c2md20161e
2011
’t Hart, P.*, Lakowski, T.M.*, Thomas, D., Frankel, A., Martin, N.I., 2011.
“Peptidic Partial Bisubstrates as Inhibitors of the Protein Arginine N-Methyltransferases.”
ChemBioChem. 12(9):1427–32. https://pubmed.ncbi.nlm.nih.gov/21560220/
2010
Lakowski, T.M.*, ‘t Hart, P.*, Ahern, C.A., Martin, N.I., Frankel, A. 2010.
“Nη-Substituted Arginyl Peptide Inhibitors of Protein Arginine N-Methyltransferases.”
ACS Chemical Biology. 5(11):1053–63. https://pubmed.ncbi.nlm.nih.gov/20701328/
*equal contribution