News

NEW PUBLICATIONS

Small molecule WDR5 inhibitors down-regulate lncRNA expression.

Chang, J.Y., Neugebauer, C., Mues genannt Koers, A., ‘t Hart, P.
_{RSC Med. Chem.}_{2024, 15, 636–640.}_{https://pubs.rsc.org/en/content/articlelanding/2024/md/d3md00605k} more

Imbuing peptide libraries with drug-likeness.

Pal, S., ‘t Hart, P.
_{Nat. Chem. Biol. 2024, 20, 140–141.}_{https://www.nature.com/articles/s41589-023-01524-x} more

Aminothiazolone Inhibitors Disrupt the Protein–RNA Interaction of METTL16 and Modulate the m⁶A RNA Modification

Yang Liu, Georg L. Goebel, Laurin Kanis, Oguz Hastürk, Claus Kemker, and Peng Wu*
_{ACS Au}_{2024, https://doi.org/10.1021/jacsau.3c00832}
more

N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1

Schmidt M, Grethe C, Recknagel S, Kipka GM, Klink N, Gersch M
_{Angew. Chem., Int. Ed., 2024, https://doi.org/10.1002/anie.202318849} more

N-Biphenyl Pyrrolinones and Dibenzofurans as RNA-Binding Protein LIN28 Inhibitors Disrupting the LIN28–Let-7 Interaction.

Lydia Borgelt, Lisa Hohnen, Jakob S. Pallesen, Pascal Hommen, Georg L. Goebel, Francesco Bosica, Yang Liu, Gavin O’Mahony*, and Peng Wu*.
_{ACS Med. Chem. Lett. 2023} more

Native semi-synthesis of isopeptide-linked substrates for specificity analysis of deubiquitinases and Ubl proteases

Zhao Z, O'Dea R, Wendrich K, Kazi N, Gersch M,
_{J Am Chem Soc, 2023, in press.} more

Macrocyclic peptides as inhibitors of WDR5–lncRNA interactions

Jen-Yao Chang,^a Cora Neugebauer,^aStefan Schmeing,^a Gulshan Amrahova^a and Peter ‘t Hart^*a
_{Chem. Commun., 2023, Advance Article} more

Targeting Ribonucleases with Small Molecules and Bifunctional Molecules

L. Borgelt and P. Wu*
_{ACS Chem. Biol. 2023}
more

Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36

R. O’Dea, N. Kazi, A. Hoffmann-Benito, Z.Zhao, S. Recknagel, K. Wendrich, P. Janning, M. Gersch
_{Nature Chemical Biology (2023)} more

Rationally designed stapled peptides allosterically inhibit PTBP1 RNA-binding

Stefan Schmeing, Gulshan Amrahova, Katrin Bigler, Jen-Yao Chang, Joseph Openy, Sunit Pal, Laura Posada, Raphael Gasper and Peter 't Hart
_{Chem. Sci., 2023, 14, 8269-8278} more

On-resin Photochemical Decarboxylative Arylation of Peptides

Pal S., Openy J., Krzyzanowski A., Noisier A., 't Hart P.
_chemRxiv_{2023, https://doi.org/10.26434/chemrxiv-2023-9kk2v} more

A translational repression reporter assay for the analysis of RNA-binding protein consensus sites.

Nowacki J., Malenica M., Schmeing S., Schiller D., Buchmuller B., Amrahova, G., ‘t Hart P.
_{RNA Biology 2023, 20(1); 85-94}

Chromenopyrazole–peptide conjugates as small-molecule based inhibitors disrupting the protein–RNA interaction of LIN28–let-7.

P. Hommen, J. Hwang, F. Huang, L. Borgelt, L. Hohnen, P. Wu
_{ChemBioChem 2023, accepted. doi: 10.1002/cbic.202300376.}

Rational design and evaluation of 2-((pyrrol-2-yl)methylene)thiophen-4-ones as RNase L inhibitors

J. Hwang, H. Haacke, L. Borgelt, X. Qiu, R. Gasper, P. Wu
_{Eur. J. Med. Chem. 2023, accepted}

Spirocyclic Chromenopyrazole Inhibitors Disrupting the Interaction between the RNA-binding protein LIN28 and Let-7

Lydia Borgelt, Fubao Huang, Lisa Hohnen, Xiaqiu Qiu, Georg L. Goebel, Pascal Hommen, Peng Wu
_{ChemBioChem 2023, accepted. doi: 10.1002/cbic.202300168.}

A translational repression reporter assay for the analysis of RNA-binding protein consensus sites

Jessica Nowacki, Mateo Malencia, Stefan Schmeig, Damian Schiller, Benjamin Buchmuller, Gulshan Amrahova, Peter 't Hart
_{RNA Biology, 2023, https://www.tandfonline.com/doi/full/10.1080/15476286.2023.2192553}

Petasis sequence reactions for the scaffold-diverse synthesis of bioactive polycyclic small molecules.

A. Avathan Veettil, J. Kirchhoff, L. Brieger, C. Strohmann, P. Wu.
_{ACS Omega. 2022, http://doi.org/10.1021/acsomega.2c06585} more

Small molecule screening of ribonuclease L binders for RNA degradation.

L. Borgelt, N. Haacke, P. Lampe, X. Qiu, R. Gasper, D. Schiller, D. Summerer, S. Sievers, P. Wu.
_{Biomed. Pharmacother.}_{2022, 154, 113589. DOI: 10.1016/j.biopha.2022.113589.} more

Kinase-targeting small-molecule inhibitors and emerging bifunctional molecules.

G. Goebel, X, Qiu, P. Wu.
_{Trends Pharmacol. Sci.}_{2022, 43 (10), 866–881. DOI: >10.1016/j.tips.2022.04.006.} more

Cyclobutane-containing scaffolds in bioactive small molecules.

C. Hui, Y. Liu, M. Jiang, P. Wu.
_{Trends Chem. 2022, 4 (8), 677–681. DOI: 10.1016/j.trechm.2022.04.006.} more

A translational repression reporter assay for the analysis of RNA-binding protein consensus sites.

Nowacki J., Malenica M., Schmeing S., Schiller D., Buchmuller B., ‘t Hart P.
_{bioRxiv, DOI: 10.1101/2022.09.05.506580}

Development of Macrocyclic PRMT5 Adaptor Protein Interaction Inhibitors.

Krzyzanowski A., Esser L.M., Willaume A., Prudent R., Peter C., ‘t Hart P., Waldmann H.
_{J. Med. Chem., 2022, DOI: https://doi.org/10.1021/acs.jmedchem.2c01273} more

Solid‐phase peptide modification via deaminative photochemical Csp3‐Csp3 bond formation using Katritzky salts.

Openy J., Amrahova G., Chang J., Noisier A., ‘t Hart P.
_{Chem. Eur. J. 28:e202201121, (2022)}

RNA-Binding Macrocyclic Peptides Front.

Sunit P., 't Hart P.
_{Mol. Biosci. 2022; 9: 883060.}

Structural basis for specific inhibition of the deubiquitinase UCHL1

Grethe C, Schmidt M, Kipka GM, O'Dea R, Gallant K, Janning P, Gersch M,
_{Nat Commun. 2022, 13(1), 5950. doi} more

Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents.

J. Hwang, X. Qiu, L. Borgelt, N. Haacke, L. Kanis S. Petroulia, R. Gasper, D. Schiller, P. Lampe, S. Sievers, J. Imig , P. Wu.
_{Bioorg. Med. Chem. 58 (2022) 116653} more

Small molecules with tetrahydroquinoline-containing Povarov scaffolds as inhibitors disrupting the ProteineRNA interaction of LIN28-let-7.

Georg L. Goebel, Lisa Hohnen, Lydia Borgelt, Pascal Hommen, Xiaqiu Qiu, Helen Lightfoot , Peng Wu
_{European Journal of Medicinal Chemistry 228, 114014, S. 1 - 14, January, 2022} more

NEW PUBLICATIONS

A translational repression reporter assay for the analysis of RNA-binding protein consensus sites.

Rational design and evaluation of 2-((pyrrol-2-yl)methylene)thiophen-4-ones as RNase L inhibitors

A translational repression reporter assay for the analysis of RNA-binding protein consensus sites.

Solid‐phase peptide modification via deaminative photochemical Csp3‐Csp3 bond formation using Katritzky salts.

RNA-Binding Macrocyclic Peptides Front.

Yang Liu from the Peng Wu Lab received the SCT Award for Best Flash Poster Presentation

Bachem AtPS Award for Peptide Science for Peter ‘t Hart

Dr. Muhammad M. Naseer received a research stay grant from the Alexander von Humboldt Foundation hosted by Dr. Peng Wu

Kim Wendrich and Nikolas Klink, Ph.D. students in the Gersch Lab, were recently honored with conference poster awards for their research on ubiquitin.

ERC Sarting Grant for Peter ‘t Hart

Peng Wu received the ICBS award

Boehringer Ingelheim Foundation supports research of Dr. Peter ‘t Hart

Sunit Pal receives highly-coveted Marie Sklodowska-Curie Postdoctoral Fellowship

Max Planck Institute of Molecular Physiology has been awarded a grant from the Bundesministeriums für Bildung und Forschung (BMBF)

Dr. Peng Wu will receive research funding from the Exploration Grants programme

Peng Wu received the 2020SCT Award for Young Investigator in Medicinal Chemistry

VolkswagenStiftung supports corona research in Dortmund

Malte Gersch accepted to the Young College of the NRW Academy of Sciences, Humanities and the Art

CGC Symposium 2019 and Arrival of the 4. Group leaderDr. Jochen Imig at the CGC

Malte Gersch, Group Leader at Chemical Genomics Centre

Peter 't Hart, Group Leader at Chemical Genomics Centre

Peng Wu, Group Leader at Chemical Genomics Centre

Chemical Genomics Centre begins new funding period

CGC Symposium 2019 and Arrival of the 4. Group leader
Dr. Jochen Imig at the CGC