Dr. Peng Wu received his Doctoral Degree in Medicinal Chemistry from Zhejiang University in 2012. He then performed postdoctoral research at the Technical University of Denmark and the University of Copenhagen. In 2016, he moved to Cambridge, MA, working as Research Fellow in Chemical Biology at Harvard, Broad Institute, BWH, and MIT. In 2018, he was appointed as Assistant Professor in the Department of Drug Design and Pharmacology at the University of Copenhagen. Since 2018, he has been Group Leader at the Chemical Genomics Centre of the Max Planck Institute of Molecular Physiology in Dortmund. His research interest originates from the interface between chemistry and biology. A central theme of his research projects is to develop novel small molecule-based modulators to target biological macromolecules.
The second one is to apply a molecular recruiter to achieve targeted degradation of RNAs. Another approach is to assemble a covalently-modified dual function molecule to target RNA-binding proteins for induced activation or deactivation. We investigate these approaches to discover chemical probes that unfold the biological mechanisms of protein-RNA regulatory networks and provide drug leads for small molecule-based therapeutics with new mechanisms of action.
The PWu Group is interested in the development of novel small molecule-based chemical modulators to manipulate the pervasive protein-RNA interactions, which impact almost all cellular events. Deregulations of the complex protein-RNA network are associated with various human diseases, while very limited modulation approaches are available. We aim to develop a platform strategy to tackle the challenging protein-RNA interactions. The first approach of our research is to use charged molecular machineries to disrupt the potent interactions between RNAs and RNA-binding proteins.